Nature Reviews Cancer
Volume 10, No 10 October 2010
FEATURED ARTICLE
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
John P. Morris, IV, Sam C. Wang & Matthias Hebrok
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CURRENT ISSUE
Review
Article series: Epigenetics and genetics
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins
Alea A. Mills
Polycomb and trithorax group proteins have opposing effects on chromatin, and either repress or activate gene expression, respectively. Therefore, the dynamic interplay between these protein families has complex effects on epigenetic regulation and consequently tumour biology.
CURRENT ISSUE
Review
Article series: Models of cancer
Harnessing transposons for cancer gene discovery
Neal G. Copeland & Nancy A. Jenkins
Transposon-based insertional mutagenesis (TIM) provides an alternative method for cancer gene discovery. This Review discusses how the mobilization of the transposon Tc1/mariner, Sleeping Beauty (SB), in mouse cells at frequencies high enough to induce cancer has facilitated the identification of the genes and signalling pathways that drive tumour formation.
CURRENT ISSUE
Review
Kaposi's sarcoma and its associated herpesvirus
Enrique A. Mesri, Ethel Cesarman & Chris Boshoff
Kaposi's sarcoma (KS) is the most common cancer in HIV-infected untreated individuals. Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious cause of KS. This Review discusses the insights into the remarkable mechanisms through which KSHV can induce KS that have been gained in the past 15 years.
CURRENT ISSUE
Perspective
Article series: Epigenetics and genetics
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis
Man Mohan, Chengqi Lin, Erin Guest & Ali Shilatifard
This article discusses the possible function of the super elongation complex (SEC) and the DOT1 H3K79 methyltransferase complex (DotCom) in leukaemia that is induced by translocation of mixed lineage leukaemia (MLL).
CURRENT ISSUE
Perspective
Cancer: an old disease, a new disease or something in between?
A. Rosalie David & Michael R. Zimmerman
This article examines the ancient history of cancer. The striking absence of malignancies in ancient physical remains might indicate the rarity of cancer in antiquity, which poses questions about the role of carcinogenic environmental factors in modern societies.
CURRENT ISSUE
Research Highlights
Tumour progression:
Disease connections
Tumorigenesis:
Dangerous micromanagement
Cancer viruses:
A two-pronged attack
Immunotherapy:
Enlisting the enemy
MORE CANCER
Web Focus Collection
Selected articles from the Nature Publishing Group including focuses on microRNAs and cancer and on stem cellsRecommended Links
Selected articles from NatureConferences
A calendar of forthcoming meetings and workshops from across the field of cancer.Migration and metastasis
A selection of Research Highlights, News and Views, Progress, Reviews, Perspectives and Research Articles published by Nature Publishing Groupjournals on the topic of migration and metastasis.
NOTICEBOARD
Hypoxia and metabolism
This Nature Reviews Cancer Collection on Hypoxia and metabolism includes a selection of recent Reviews, Perspectives and Research Highlights that provide insight into the roles of these processes in tumour biology and therapy.
Pathway Interaction Database
For a visual, up–to–date view of the proteins and genes that interact with and regulate p53.
Nature Reports Stem Cells
Nature Reports Stem Cells for the latest news, research, comment and analysis about stem cells and their implications.
MYC
Throughout 2008 and 2009, we will publish a series of specially commissioned articles that discuss the key issues and our current knowledge of MYC and cancer.
What is translational cancer research?
What does translational cancer research mean to you? Compare your views with those of our podcast panel from the new Cancer Research UK Cambridge Research Institute.
Bruce Ponder, Fiona Watt, Duncan Odom & David Neal
Bruce Ponder, Fiona Watt, Duncan Odom & David Neal
Mouse models
The evolution of genetically engineered mouse models of cancer
Kristopher K. Frese and David A. Tuveson
Kristopher K. Frese and David A. Tuveson
Tumour Microenvironment
The final two articles in our series on the tumour microenvironment are published in this month�s issue. All the articles that have appeared in this series can be found online atwww.nature.com/nrc/series/tumourmicro
Milestones in Cancer
Milestones in Cancer is a collaborative project involving three journals - Nature, Nature Medicine and Nature Reviews Cancer - and celebrates more than 100 years of discoveries in the field of cancer.
2009 Journal Citation Report (Thomson Reuters, 2010)
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