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Nature 467, 406-407 (23 September 2010) | doi:10.1038/467406a; Published online 22 September 2010
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Chief Research Manager / Dy. General Manager (Biotechnology)
- Indian Oil Corporation Ltd
- Faridabad India
Bioinformatician (Ensembl Genomes)
- European Bioinformatics Institute (EBI)
- Cambridge United Kingdom
Gene expression: The coherent Mediator
Rolf Ohlsson1
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Abstract
Enhancer sequences increase gene transcription with the help of a co-activator complex, the Mediator. Another protein complex — cohesin — seems to work with Mediator to bring together enhancers and promoters. See Article p. 430
The multiprotein Mediator complex is a general regulator of gene transcription. In eukaryotic organisms (such as animals, plants and fungi), it allows high levels of activator-dependent transcription by bringing together diffusible trans-acting factors, such as proteins that regulate gene expression, and the basal transcriptional machinery at the promoter sequences1.
- Rolf Ohlsson is in the Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Email: rolf.ohlsson@ki.se
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